Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The Nramp1 protein and its role in resistance to infection and macrophage function.

Proceedings of the Association of American Physicians - 1 Jan 2000

Canonne-Hergaux F, Gruenheid S, Govoni G, Gros P

Abstract excerpt

Susceptibility to infectious diseases is under genetic control in humans. Animal models provide an ideal tool to study the genetic component of susceptibility and to identify candidate genes that can then be tested for association or linkage studies in human populations from endemic areas of disease. The Nramp1 gene was isolated by positional cloning the host resistance locus Bcg/Ity/Lsh, and mutations at this...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cations
Share to Infections
Share to Ion Transport

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Iron-Binding Proteins

Share to Lysosomes

Share to Macrophage Activation

Share to Mycobacterium Infections

Share to Phagocytosis

Source

Identifiers

PMID: 10417735
DOI: 10.1046/j.1525-1381.1999.99236.x

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The Nramp1 protein and its role in resistance to infection and macrophage function.PMID 10417735Read ↗

Structure and function of the natural-resistance-associated macrophage protein (Nramp1), a candidate protein for infectious and autoimmune disease susceptibility.Semantic proximity Read ↗

Genetic susceptibility to intracellular infections: Nramp1, macrophage function and divalent cations transport.Semantic proximity Read ↗

Genetic regulation of macrophage activation: understanding the function of Nramp1 (=Ity/Lsh/Bcg).Semantic proximity Read ↗

The Ity/Lsh/Bcg locus: natural resistance to infection with intracellular parasites is abrogated by disruption of the Nramp1 gene.Semantic proximity Read ↗

Infection genomics: Nramp1 as a major determinant of natural resistance to intracellular infections.Semantic proximity Read ↗

Nramp1 locus encodes a 65 kDa interferon-γ-inducible protein in murine macrophagesSemantic proximity Read ↗

Human natural resistance-associated macrophage protein: cDNA cloning, chromosomal mapping, genomic organization, and tissue-specific expression.Semantic proximity Read ↗

The Bcg host-resistance gene.Semantic proximity Read ↗

Localisation of Nramp1 in macrophages: modulation with activation and infection.Semantic proximity Read ↗

Evidence for a link between iron metabolism and Nramp1 gene function in innate resistance against Mycobacterium avium.Semantic proximity Read ↗

Divalent cation transport and susceptibility to infectious and autoimmune disease: continuation of the Ity/Lsh/Bcg/Nramp1/Slc11a1 gene story.Semantic proximity Read ↗

Functional analysis of the human NRAMP family expressed in fission yeast.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.