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Article

Host resistance factor SLC11A1 restricts Salmonella growth through magnesium deprivation.

Science (New York, N.Y.) - 22 Nov 2019

Cunrath Olivier, Bumann Dirk

Abstract excerpt

The pleiotropic host resistance factor SLC11A1 (NRAMP1) defends against diverse intracellular pathogens in mammals by yet-unknown mechanisms. We compared Salmonella infection of coisogenic mice with different SLC11A1 alleles. SLC11A1 reduced Salmonella replication and triggered up-regulation of uptake systems for divalent metal cations but no other stress responses. SLC11A1 modestly diminished iron availability...

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Identifiers

PMID: 31753999
DOI: 10.1126/science.aax7898

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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