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The solute carrier family 11 transporters: a bridge between iron homeostasis and tumor biology

10 Jul 2025

Abstract excerpt

Iron is an essential trace element in the human body, and its imbalance is closely linked to the initiation and progression of various malignancies. The solute carrier family 11 (SLC11) transporters, comprising SLC11A1 and SLC11A2, play pivotal roles in iron metabolism and cellular homeostasis, processes intricately linked to oncogenesis. SLC11A1, primarily expressed in macrophages, modulates immune responses and...

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PMID: 40640903
DOI: 10.1186/s12964-025-02293-x

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