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SLC11A1 genetic variation and low expression may cause immune response impairment in TB patients.

Genes and immunity - 1 Apr 2022

Shahzad Faheem, Bashir Noman, Ali Atia, Nadeem Ayesha, Ammar Ali, Kashif Mohammad, Javaid Khursheed, Jahan Shah, Tahir Romeeza, Rizwan Muhammad, Mushtaq Abid, Afzal Nadeem

Abstract excerpt

Tuberculosis (TB) is caused by Mycobacterium tuberculosis. Host genetic factors are important for the detection of TB susceptibility. SLC11A1 is located in monocyte phagolysosomes that help to limit M. tuberculosis growth by transferring divalent cations across the membrane. Genetic variation in SLC11A1 may alter its expression and increase the susceptibility of individuals to TB. The current study aimed to...

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PMID: 35140349
DOI: 10.1038/s41435-022-00165-9

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