Article
Sequence mutations in teleost cardiac troponin C that are permissive of high Ca2+ affinity of site II.
American journal of physiology. Cell physiology - 1 May 2003
Gillis Todd E, Moyes Chris D, Tibbits Glen F
Abstract excerpt
Cardiac myofibrils isolated from trout heart have been demonstrated to have a higher sensitivity for Ca(2+) than mammalian cardiac myofibrils. Using cardiac troponin C (cTnC) cloned from trout and mammalian hearts, we have previously demonstrated that this comparatively high Ca(2+) sensitivity is due, in part, to trout cTnC (ScTnC) having twice the Ca(2+) affinity of mammalian cTnC (McTnC) over a broad range of...
Topics
- Amino Acid Sequence
- Animals
- Binding Sites
- Binding, Competitive
- Calcium
- Fishes
- Hydrogen-Ion Concentration
- Mammals
- Molecular Sequence Data
- Mutation
- Myocardium
- Oncorhynchus mykiss
- Peptide Fragments
- Species Specificity
- Temperature
- Troponin C