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Article

Sequence mutations in teleost cardiac troponin C that are permissive of high Ca2+ affinity of site II.

American journal of physiology. Cell physiology - 1 May 2003

Gillis Todd E, Moyes Chris D, Tibbits Glen F

Abstract excerpt

Cardiac myofibrils isolated from trout heart have been demonstrated to have a higher sensitivity for Ca(2+) than mammalian cardiac myofibrils. Using cardiac troponin C (cTnC) cloned from trout and mammalian hearts, we have previously demonstrated that this comparatively high Ca(2+) sensitivity is due, in part, to trout cTnC (ScTnC) having twice the Ca(2+) affinity of mammalian cTnC (McTnC) over a broad range of...

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PMID: 12519747
DOI: 10.1152/ajpcell.00339.2002

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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