Article
Increasing mammalian cardiomyocyte contractility with residues identified in trout troponin C.
Physiological genomics - 16 Jun 2005
Gillis Todd E, Liang Bo, Chung Franca, Tibbits Glen F
Abstract excerpt
The Ca2+ sensitivity of force generation in trout cardiac myocytes is significantly greater than that from mammalian hearts. One mechanism that we have suggested to be responsible, at least in part, for this high Ca2+ sensitivity is the isoform of cardiac troponin C (cTnC) found in trout hearts (ScTnC), which has greater than twice the Ca2+ affinity of mammalian cTnC (McTnC). Here, through a series of mutations,...
Topics
- Amino Acid Sequence
- Amino Acids
- Animals
- Calcium
- Molecular Sequence Data
- Mutation
- Myocardial Contraction
- Myocytes, Cardiac
- Protein Binding
- Rabbits
- Sequence Alignment