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Article

Effect of temperature and the F27W mutation on the Ca2+ activated structural transition of trout cardiac troponin C.

Biochemistry - 3 Jun 2003

Gillis Todd E, Blumenschein Tharin M A, Sykes Brian D, Tibbits Glen F

Abstract excerpt

The Ca(2+) sensitivity of cardiac contractile element is reduced at lower temperatures, in contrast to that in fast skeletal muscle. Cardiac troponin C (cTnC) replacement in mammalian skinned fibers showed that TnC plays a critical role in this phenomenon (Harrison and Bers, (1990), Am. J. Physiol. 258, C282-8). Understanding the differences in affinity and structure between cTnCs from cold-adapted ectothermic...

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Identifiers

PMID: 12767223
DOI: 10.1021/bi0340494

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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