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Article

Structural and functional consequences of cardiac troponin C L57Q and I61Q Ca(2+)-desensitizing variants.

Archives of biochemistry and biophysics - 1 Jul 2013

Wang Dan, McCully Michelle E, Luo Zhaoxiong, McMichael Jonathan, Tu An-Yue, Daggett Valerie, Regnier Michael

Abstract excerpt

Two cTnC variants, L57Q and I61Q, both of which are located on helix C within the N domain of cTnC, were originally reported in the skeletal muscle system [Tikunova, Davis, J. Biol. Chem. 279 (2004) 35341-35352], as the analogous L58Q and I62Q sTnC, and demonstrated a decreased Ca(2+) binding affinity. Here, we provide detailed characterization of structure-function relationships for these two cTnC variants, to...

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Identifiers

PMID: 23454346
DOI: 10.1016/j.abb.2013.02.006
PMCID: PMC3657564

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Source receipt: pubmed, retrieved 7 Sept 2026.

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