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Article

Familial hypertrophic cardiomyopathy-related cardiac troponin C mutation L29Q affects Ca2+ binding and myofilament contractility.

Physiological genomics - 22 Apr 2008

Liang Bo, Chung Franca, Qu Yang, Pavlov Dmitri, Gillis Todd E, Tikunova Svetlana B, Davis Jonathan P, Tibbits Glen F

Abstract excerpt

The cardiac troponin C (cTnC) mutation, L29Q, has been found in a patient with familial hypertrophic cardiomyopathy. We previously showed that L29, together with neighboring residues, Asp2, Val28, and Gly30, plays an important role in determining the Ca(2+) affinity of site II, the regulatory site of mammalian cardiac troponin C (McTnC). Here we report on the Ca(2+) binding characteristics of L29Q McTnC and...

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Identifiers

PMID: 18285522
DOI: 10.1152/physiolgenomics.00154.2007

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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