Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Multipotent cell lineages in early mouse development depend on SOX2 function.

Genes & development - 1 Jan 2003

Avilion Ariel A, Nicolis Silvia K, Pevny Larysa H, Perez Lidia, Vivian Nigel, Lovell-Badge Robin

Abstract excerpt

Each cell lineage specified in the preimplantation mammalian embryo depends on intrinsic factors for its development, but there is also mutual interdependence between them. OCT4 is required for the ICM/epiblast lineage, and at transient high levels for extraembryonic endoderm, but also indirectly through its role in regulating Fgf4 expression, for the establishment and proliferation of extraembryonic ectoderm...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Chorion
Share to Ectoderm
Share to Embryo Transfer

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to HMGB Proteins

Share to Multipotent Stem Cells

Share to Octamer Transcription Factor-3

Share to SOXB1 Transcription Factors

Share to Trophoblasts

Source

Open in PubMed Open full text

Identifiers

PMID: 12514105
DOI: 10.1101/gad.224503
PMCID: PMC195970

Genes

SOX2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Multipotent cell lineages in early mouse development depend on SOX2 function.PMID 12514105Read ↗

Klf5 regulates lineage formation in the pre-implantation mouse embryo.Semantic proximity Read ↗

Transgene directed induction of a stem cell-derived human embryo modelSemantic proximity Read ↗

Smad2 signaling in extraembryonic tissues determines anterior-posterior polarity of the early mouse embryo.Semantic proximity Read ↗

Pluripotent stem cell-derived model of the post-implantation human embryoSemantic proximity Read ↗

Human Naïve Epiblast Cells Possess Unrestricted Lineage PotentialSemantic proximity Read ↗

Base editing in bovine embryos reveals a species-specific role of SOX2 in regulation of pluripotencySemantic proximity Read ↗

Suppression of ERK signalling promotes pluripotent epiblast in the human blastocystSemantic proximity Read ↗

Transcription factor TEAD4 specifies the trophectoderm lineage at the beginning of mammalian development.Semantic proximity Read ↗

Trophoblast Stem Cells1Semantic proximity Read ↗

Divergent destinies: insights into the molecular mechanisms underlying EPI and PE fate determinationSemantic proximity Read ↗

NANOG is repurposed after implantation to repress Sox2 and begin pluripotency extinctionSemantic proximity Read ↗

NANOG is required to form the epiblast and maintain pluripotency in the bovine embryo.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.