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Article

Transcription factor TEAD4 specifies the trophectoderm lineage at the beginning of mammalian development.

Development (Cambridge, England) - 1 Nov 2007

Yagi Rieko, Kohn Matthew J, Karavanova Irina, Kaneko Kotaro J, Vullhorst Detlef, DePamphilis Melvin L, Buonanno Andres

Abstract excerpt

Specification of cell lineages in mammals begins shortly after fertilization with formation of a blastocyst consisting of trophectoderm, which contributes exclusively to the placenta, and inner cell mass (ICM), from which the embryo develops. Here we report that ablation of the mouse Tead4 gene results in a preimplantation lethal phenotype, and TEAD4 is one of two highly homologous TEAD transcription factors that...

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Source

Identifiers

PMID: 17913785
DOI: 10.1242/dev.010223

Genes

TEAD4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Transcription factor TEAD4 specifies the trophectoderm lineage at the beginning of mammalian development.PMID 17913785Read ↗

Tead4 is required for specification of trophectoderm in pre-implantation mouse embryos.Semantic proximity Read ↗

TEAD4 regulates trophectoderm differentiation upstream of CDX2 in a GATA3-independent manner in the human preimplantation embryoSemantic proximity Read ↗

TEAD4 ensures postimplantation development by promoting trophoblast self-renewal: An implication in early human pregnancy lossSemantic proximity Read ↗

Lineage segregation in human pre-implantation embryos is specified by YAP1 and TEAD1Semantic proximity Read ↗

VGLL1 contributes to both the transcriptome and epigenome of the developing trophoblast compartmentSemantic proximity Read ↗

The GATA transcriptional program dictates cell fate equilibrium to establish the maternal–fetal exchange interface and fetal developmentSemantic proximity Read ↗

Primary Differentiation in the Human Blastocyst: Comparative Molecular Portraits of Inner Cell Mass and Trophectoderm CellsSemantic proximity Read ↗

CDX2 regulates multiple trophoblast genes in bovine trophectoderm CT‐1 cellsSemantic proximity Read ↗

Ets2 is required for trophoblast stem cell self-renewal.Semantic proximity Read ↗

Aberrant Expression Patterns of Genes Involved in Segregation of Inner Cell Mass and Trophectoderm Lineages in Bovine Embryos Derived from Somatic Cell Nuclear TransferSemantic proximity Read ↗

GATA-regulated transcriptional program dictate cell fate equilibrium to establish the maternal-fetal exchange interface and fetal developmentSemantic proximity Read ↗

SALL2 constrains TEAD4 by maintaining repressive chromatin to restrict trophectoderm identitySemantic proximity Read ↗

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