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Suppression of ERK signalling promotes pluripotent epiblast in the human blastocyst

2024-02-04

Abstract excerpt

Studies in the mouse demonstrate the importance of fibroblast growth factor (FGF) and extra-cellular receptor tyrosine kinase (ERK) in specification of embryo-fated epiblast and yolk-sac-fated hypoblast cells from uncommitted inner cell mass (ICM) cells prior to implantation. Molecular mechanisms regulating specification of early lineages in human development are comparatively unclear. Here we show that exogenous...

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Literature Corpus work
f2c13f97-23da-50f3-8434-195c1b2ba9c2
DOI
10.1101/2024.02.01.578414
Open publication

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Suppression of ERK signalling promotes pluripotent epiblast in the human blastocystDOI 10.1101/2024.02.01.578414
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