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Trophoblast Stem Cells1

25 Nov 2010

Abstract excerpt

Trophoblast stem cells (TSC) are the precursors of the differentiated cells of the placenta. In the mouse, TSC can be derived from outgrowths of either blastocyst polar trophectoderm (TE) or extraembryonic ectoderm (ExE), which originates from polar TE after implantation. The mouse TSC niche appears to be located within the ExE adjacent to the epiblast, on which it depends for essential growth factors, but...

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PMID: 21106963
DOI: 10.1095/biolreprod.110.088724

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