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Article

Klf5 regulates lineage formation in the pre-implantation mouse embryo.

Development (Cambridge, England) - 1 Dec 2010

Lin Suh-Chin J, Wani Maqsood A, Whitsett Jeffrey A, Wells James M

Abstract excerpt

Kruppel-like transcription factors (Klfs) are essential for the induction and maintenance of pluripotency of embryonic stem cells (ESCs), yet little is known about their roles in establishing the three lineages of the pre-implantation embryo. Here, we show that Klf5 is required for the formation of the trophectoderm (TE) and the inner cell mass (ICM), and for repressing primitive endoderm (PE) development....

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Identifiers

PMID: 20980403
DOI: 10.1242/dev.054775
PMCID: PMC2976279

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