Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Divergent destinies: insights into the molecular mechanisms underlying EPI and PE fate determination

8 Jan 2025

Abstract excerpt

Mammalian pre-implantation development is entirely devoted to the specification of extra-embryonic lineages, which are fundamental for embryo morphogenesis and support. The second fate decision is taken just before implantation, as defined by the epiblast (EPI) and the primitive endoderm (PE) specification. Later, EPI forms the embryo proper and PE contributes to the formation of the yolk sac. The formation of...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to CRISPR and Genetic Engineering
Share to Pluripotent Stem Cells Research
Share to Reproductive Biology and Fertility

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 39779220
DOI: 10.26508/lsa.202403091

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Divergent destinies: insights into the molecular mechanisms underlying EPI and PE fate determinationPMID 39779220Read ↗

Revisiting trophectoderm-inner cell mass lineage segregation in the mammalian preimplantation embryoSemantic proximity Read ↗

Signaling pathways in mammalian preimplantation development: Linking cellular phenotypes to lineage decisions.Semantic proximity Read ↗

Totipotency and lineage segregation in the human embryoSemantic proximity Read ↗

Efficient Reprogramming of the Epiblast Enables the Generation of Cloned MiceSemantic proximity Read ↗

Mechanisms behind the fate of early chromosomal and transcriptional heterogeneities in the mouse embryoSemantic proximity Read ↗

Nodal cis-regulatory elements reveal epiblast and primitive endoderm heterogeneity in the peri-implantation mouse embryo.Semantic proximity Read ↗

A single-cell atlas of pig gastrulation as a resource for comparative embryologySemantic proximity Read ↗

Suppression of ERK signalling promotes pluripotent epiblast in the human blastocystSemantic proximity Read ↗

Making the blastocyst: lessons from the mouseSemantic proximity Read ↗

Spatiotemporal sequence of mesoderm and endoderm lineage segregation during mouse gastrulation.Semantic proximity Read ↗

Cross-species comparison of mouse and human preimplantation development with an emphasis on lineage specificationSemantic proximity Read ↗

A single cell characterisation of human embryogenesis identifies pluripotency transitions and putative anterior hypoblast centreSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.