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Article

src homology 2 domain-containing tyrosine phosphatase SHP-1 controls the development of allergic airway inflammation.

The Journal of clinical investigation - 1 Jan 2003

Kamata Tohru, Yamashita Masakatsu, Kimura Motoko, Murata Kaoru, Inami Masamichi, Shimizu Chiori, Sugaya Kaoru, Wang Chrong-Reen, Taniguchi Masaru, Nakayama Toshinori

Abstract excerpt

Th2 cells are generated from naive CD4 T cells upon T cell receptor (TCR) recognition of antigen and IL-4 stimulation and play crucial roles in humoral immunity against infectious microorganisms and the pathogenesis of allergic and autoimmune diseases. A tyrosine phosphatase, SHP-1, that contains src homology 2 (SH2) domains is recognized as a negative regulator for various intracellular signaling molecules,...

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Identifiers

PMID: 12511594
DOI: 10.1172/JCI15719
PMCID: PMC151831

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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