Article
Establishment and characterization of pro-B cell lines from motheaten mutant mouse defective in SHP-1 protein tyrosine phosphatase.
Immunology letters - 1 Sept 1998
Miyamoto A, Kunisada T, Yamazaki H, Miyake K, Nishikawa S I, Sudo T, Shultz L D, Hayashi S I
Abstract excerpt
Mice homozygous for the motheaten (Hcph(me)) mutation lack a functional SHP-1 protein tyrosine phosphatase, show severe immunologic dysregulation and die at an early age. Severe pneumonitis in me/me mice is associated with abnormal proliferation of macrophages and granulocytes. Overgrowth of macr...
Topics
- Animals
- Apoptosis
- B-Lymphocytes
- Bone Marrow Cells
- Cell Cycle
- Cell Line
- Female
- Gene Rearrangement, B-Lymphocyte, Heavy Chain
- Hematopoietic Stem Cells
- Interleukin-7
- Intracellular Signaling Peptides and Proteins
- Male
- Mice
- Mice, Inbred C3H