Shb deficient mice display an augmented TH2 response in peripheral CD4+ T cells.

doi:10.1186/1471-2172-12-3

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Article

Shb deficient mice display an augmented TH2 response in peripheral CD4+ T cells.

BMC immunology - 11 Jan 2011

Gustafsson Karin, Calounova Gabriela, Hjelm Fredrik, Kriz Vitezslav, Heyman Birgitta, Grönvik Kjell-Olov, Mostoslavsky Gustavo, Welsh Michael

Abstract excerpt

BACKGROUND: Shb, a ubiquitously expressed Src homology 2 domain-containing adaptor protein has previously been implicated in the signaling of various tyrosine kinase receptors including the TCR. Shb associates with SLP76, LAT and Vav, all important components in the signaling cascade governing T cell function and development. A Shb knockout mouse was recently generated and the aim of the current study was to...

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PMID: 21223549
DOI: 10.1186/1471-2172-12-3
PMCID: PMC3024994

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.