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Article

Distinct roles for neutrophils and dendritic cells in inflammation and autoimmunity in motheaten mice.

Immunity - 21 Mar 2013

Abram Clare L, Roberge Gray L, Pao Lily I, Neel Benjamin G, Lowell Clifford A

Abstract excerpt

The motheaten mouse has long served as a paradigm for complex autoimmune and inflammatory disease. Null mutations in Ptpn6, which encodes the nonreceptor protein-tyrosine phosphatase Shp1, cause the motheaten phenotype. However, Shp1 regulates multiple signaling pathways in different hematopoietic cell types, so the cellular and molecular mechanism of autoimmunity and inflammation in the motheaten mouse has...

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Identifiers

PMID: 23521885
DOI: 10.1016/j.immuni.2013.02.018
PMCID: PMC3613338

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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