Article
Genetic analysis reveals cell type-specific regulation of receptor tyrosine kinase c-Kit by the protein tyrosine phosphatase SHP1.
The Journal of experimental medicine - 1 Sept 1996
Lorenz U, Bergemann A D, Steinberg H N, Flanagan J G, Li X, Galli S J, Neel B G
Abstract excerpt
Receptor protein tyrosine kinases (RTKs) transmit downstream signals via interactions with secondary signaling molecules containing SH2 domains. Although many SH2-phosphotyrosyl interactions have been defined in vitro, little is known about the physiological significance of specific RTK/SH2 inter...
Topics
- Animals
- Cell Count
- Female
- Genotype
- Hematopoietic Stem Cells
- Intracellular Signaling Peptides and Proteins
- Male
- Mast Cells
- Mice
- Protein Tyrosine Phosphatase, Non-Receptor Type 6
- Protein Tyrosine Phosphatases
- Proto-Oncogene Proteins c-kit