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Article

Genetic analysis reveals cell type-specific regulation of receptor tyrosine kinase c-Kit by the protein tyrosine phosphatase SHP1.

The Journal of experimental medicine - 1 Sept 1996

Lorenz U, Bergemann A D, Steinberg H N, Flanagan J G, Li X, Galli S J, Neel B G

Abstract excerpt

Receptor protein tyrosine kinases (RTKs) transmit downstream signals via interactions with secondary signaling molecules containing SH2 domains. Although many SH2-phosphotyrosyl interactions have been defined in vitro, little is known about the physiological significance of specific RTK/SH2 interactions in vivo. Also, little is known about the mechanisms by which specific RTKs interact with and/or are regulated...

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Identifiers

PMID: 9064328
DOI: 10.1084/jem.184.3.1111
PMCID: PMC2192792

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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