Article
Severe defects in immunity and hematopoiesis caused by SHP-1 protein-tyrosine-phosphatase deficiency.
Trends in biotechnology - 1 Aug 1997
Shultz L D, Rajan T V, Greiner D L
Abstract excerpt
Spontaneous mouse mutations that cause severe immunodeficiency or autoimmunity are invaluable tools with which to investigate the mammalian immune system. Mutations at the 'motheaten' locus result in severe immunological dysfunction due to disruption of the structural gene encoding Src-homology 2...
Topics
- Animals
- Gene Expression Regulation, Enzymologic
- Hematopoiesis
- Immunologic Deficiency Syndromes
- Intracellular Signaling Peptides and Proteins
- Mutation
- Protein Phosphatase 1
- Protein Tyrosine Phosphatase, Non-Receptor Type 11
- Protein Tyrosine Phosphatase, Non-Receptor Type 6
- Protein Tyrosine Phosphatases