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Article

Unexpected phenotype of mice lacking Shcbp1, a protein induced during T cell proliferation.

PloS one - 1 Jan 2014

Buckley Monica W, Arandjelovic Sanja, Trampont Paul C, Kim Taeg S, Braciale Thomas J, Ravichandran Kodi S

Abstract excerpt

T cell development and activation are highly regulated processes, and their proper execution is important for a competent immune system. Shc SH2-domain binding protein-1 (Shcbp1) is an evolutionarily conserved protein that binds to the adaptor protein ShcA. Studies in Drosophila and in cell lines have strongly linked Shcbp1 to cell proliferation, embryonic development, growth factor signaling, and tumorigenesis....

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 25153088
DOI: 10.1371/journal.pone.0105576
PMCID: PMC4143286

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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