Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Investigations into the regulation and function of the SH2 domain-containing protein-tyrosine phosphatase, SHP-1.

Immunologic research - 1 Jan 2006

Tsui Florence W L, Martin Alberto, Wang John, Tsui Hing Wo

Abstract excerpt

Our laboratory is interested in identifying genes relevant to diseases. Our approach is to use spontaneous mouse mutants with immunological defects and decipher the molecular basis of the phenotypes. In the early 1990s, our attention was focused on the motheaten and viable motheaten mouse mutants. We used these mutant mice as a model system for elucidating the genetic and cellular events contributing to...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Gene Expression Regulation, Enzymologic
Share to Immunologic Deficiency Syndromes

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Intracellular Signaling Peptides and Proteins

Share to Mice, Mutant Strains

Share to Neoplasms

Share to Protein Tyrosine Phosphatase, Non-Receptor Type 6

Share to Protein Tyrosine Phosphatases

Share to src Homology Domains

Source

Identifiers

PMID: 17003515
DOI: 10.1385/IR:35:1:127

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Investigations into the regulation and function of the SH2 domain-containing protein-tyrosine phosphatase, SHP-1.PMID 17003515Read ↗

Severe defects in immunity and hematopoiesis caused by SHP-1 protein-tyrosine-phosphatase deficiency.Semantic proximity Read ↗

Shp1 function in myeloid cells.Semantic proximity Read ↗

src homology 2 domain-containing tyrosine phosphatase SHP-1 controls the development of allergic airway inflammation.Semantic proximity Read ↗

Establishment and characterization of pro-B cell lines from motheaten mutant mouse defective in SHP-1 protein tyrosine phosphatase.Semantic proximity Read ↗

Identification of PTP1C mutation as the genetic defect in motheaten and viable motheaten mice: a step toward defining the roles of protein tyrosine phosphatases in the regulation of hemopoietic cell differentiation and function.Semantic proximity Read ↗

Unexpected phenotype of mice lacking Shcbp1, a protein induced during T cell proliferation.Semantic proximity Read ↗

Dephosphorylation of ZAP-70 and inhibition of T cell activation by activated SHP1.Semantic proximity Read ↗

Requirement of Shp-2 tyrosine phosphatase in lymphoid and hematopoietic cell development.Semantic proximity Read ↗

SHP-1 variant proteins are absent in motheaten mice despite presence of splice variant transcripts with open reading frames.Semantic proximity Read ↗

B and T cells are not required for the viable motheaten phenotype.Semantic proximity Read ↗

Genetic analysis reveals cell type-specific regulation of receptor tyrosine kinase c-Kit by the protein tyrosine phosphatase SHP1.Semantic proximity Read ↗

Loss of Shp1 impairs myeloid cell function and causes lethal inflammation in zebrafish larvaeSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.