Article
Signalling by the W/Kit receptor tyrosine kinase is negatively regulated in vivo by the protein tyrosine phosphatase Shp1.
Nature genetics - 1 Jul 1996
Paulson R F, Vesely S, Siminovitch K A, Bernstein A
Abstract excerpt
Protein tyrosine phosphorylation plays a key role in regulating eukaryotic cell proliferation and differentiation. Genetic analysis in invertebrates has been invaluable for dissecting the signalling events downstream of receptor tyrosine kinases (RTKs). We have used this approach in mammals to an...
Topics
- Anemia
- Animals
- Autoimmune Diseases
- Calcium-Calmodulin-Dependent Protein Kinases
- Gene Expression Regulation
- Genes, Lethal
- Genetic Complementation Test
- Homozygote
- Intracellular Signaling Peptides and Proteins
- Lung Diseases
- Mast Cells
- Mice
- Mice, Inbred C3H
- Mice, Inbred C57BL
- Mice, Mutant Strains
- Models, Biological
- Mutation
- Phenotype