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Article

Signalling by the W/Kit receptor tyrosine kinase is negatively regulated in vivo by the protein tyrosine phosphatase Shp1.

Nature genetics - 1 Jul 1996

Paulson R F, Vesely S, Siminovitch K A, Bernstein A

Abstract excerpt

Protein tyrosine phosphorylation plays a key role in regulating eukaryotic cell proliferation and differentiation. Genetic analysis in invertebrates has been invaluable for dissecting the signalling events downstream of receptor tyrosine kinases (RTKs). We have used this approach in mammals to analyse the interactions between the Kit RTK encoded by the murine Dominant white spotting (W) locus and the Shp1 protein...

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PMID: 8673130
DOI: 10.1038/ng0796-309

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

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Signalling by the W/Kit receptor tyrosine kinase is negatively regulated in vivo by the protein tyrosine phosphatase Shp1.PMID 8673130Read ↗

Genetic analysis reveals cell type-specific regulation of receptor tyrosine kinase c-Kit by the protein tyrosine phosphatase SHP1.Semantic proximity Read ↗

The Wsh, W57, and Ph Kit Expression Mutations Define Tissue-Specific Control Elements Located Between −23 and −154 kb Upstream of KitSemantic proximity Read ↗

Long-range genomic rearrangements upstream of Kit dysregulate the developmental pattern of Kit expression in W57 and Wbanded mice and interfere with distinct steps in melanocyte development.Semantic proximity Read ↗

The kit-ligand (steel factor) and its receptor c-kit/W: pleiotropic roles in gametogenesis and melanogenesis.Semantic proximity Read ↗

The murine W/c-kit and Steel loci and the control of hematopoiesis.Semantic proximity Read ↗

W-sash affects positive and negative elements controlling c-kit expression: ectopic c-kit expression at sites of kit-ligand expression affects melanogenesis.Semantic proximity Read ↗

The Wsh and Ph mutations affect the c-kit expression profile: c-kit misexpression in embryogenesis impairs melanogenesis in Wsh and Ph mutant mice.Semantic proximity Read ↗

Signal transduction by normal isoforms and W mutant variants of the Kit receptor tyrosine kinase.Semantic proximity Read ↗

src homology 2 domain-containing tyrosine phosphatase SHP-1 controls the development of allergic airway inflammation.Semantic proximity Read ↗

W mutant mice with mild or severe developmental defects contain distinct point mutations in the kinase domain of the c-kit receptor.Semantic proximity Read ↗

Mast cell-deficient W-sash c-kit mutant Kit W-sh/W-sh mice as a model for investigating mast cell biology in vivo.Semantic proximity Read ↗

Molecular bases of dominant negative and loss of function mutations at the murine c-kit/white spotting locus: W37, Wv, W41 and W.Semantic proximity Read ↗

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