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Article

Membrane expression of proteinase 3 is genetically determined.

Journal of the American Society of Nephrology : JASN - 1 Jan 2003

Schreiber Adrian, Busjahn Andreas, Luft Friedrich C, Kettritz Ralph

Abstract excerpt

Isolated human neutrophils exhibit a bimodal membrane proteinase 3 (PR3) expression. PR3 is the main target antigen in Wegener granulomatosis (WG). Cells with low expression can be easily distinguished from cell subsets with high expression. In a recent study, a large neutrophil subset expressing membrane PR3 (mPR3+) was a risk factor for systemic ANCA-associated vasculitis. PR3 membrane expression patterns are...

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Identifiers

PMID: 12506139
DOI: 10.1097/01.asn.0000040751.83734.d1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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