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Article

Proteinase 3 gene polymorphisms and Wegener's granulomatosis.

Kidney international - 1 Dec 2000

Gencik M, Meller S, Borgmann S, Fricke H

Abstract excerpt

BACKGROUND: Wegener's granulomatosis (WG) is a rare systemic autoimmune disease characterized by small-vessel vasculitis leading to organ damage and the presence of antineutrophil cytoplasmic autoantibodies (ANCAs). ANCAs were shown to be involved in the pathogenesis of the disease by increasing adhesion of polymorphonuclear cells (PMNs) to endothelial cells and through activation of primed PMN. The main...

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PMID: 11115080
DOI: 10.1046/j.1523-1755.2000.00430.x

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