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Article

Membrane proteinase 3 and Wegener's granulomatosis.

Clinical nephrology - 1 Dec 2005

von Vietinghoff S, Schreiber A, Otto B, Choi M, Göbel U, Kettritz R

Abstract excerpt

Proteinase 3 (PR3) is found in neutrophil and monocyte lysosomal granules. Anti-neutrophil cytoplasmatic antibodies (ANCA) with specificity for PR3 are characteristic for patients with Wegener's granulomatosis. The interaction of ANCA with neutrophilic ANCA antigens is necessary for the development of ANCA-associated diseases. ANCA bind to membrane-expressed PR3 and induce full-blown activation in primed...

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Share to Antibodies, Antineutrophil Cytoplasmic
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 16370159
DOI: 10.5414/cnp64453

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

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Membrane proteinase 3 and Wegener's granulomatosis.PMID 16370159Read ↗

Membrane expression of proteinase 3 is genetically determined.Semantic proximity Read ↗

A large subset of neutrophils expressing membrane proteinase 3 is a risk factor for vasculitis and rheumatoid arthritis.Semantic proximity Read ↗

Proteinase 3, the Wegener autoantigen, is externalized during neutrophil apoptosis: evidence for a functional association with phospholipid scramblase 1 and interference with macrophage phagocytosis.Semantic proximity Read ↗

Bimodal distribution of proteinase 3 (PR3) surface expression reflects a constitutive heterogeneity in the polymorphonuclear neutrophil pool.Semantic proximity Read ↗

Constitutive membrane expression of proteinase 3 (PR3) and neutrophil activation by anti-PR3 antibodies.Semantic proximity Read ↗

Proteinase 3 gene polymorphisms and Wegener's granulomatosis.Semantic proximity Read ↗

Republished: Antineutrophil cytoplasmic antibody-associated vasculitides: is it time to split up the group?Semantic proximity Read ↗

Pathways to ANCA production: from differentiation of dendritic cells by proteinase 3 to B lymphocyte maturation in Wegener's granuloma.Semantic proximity Read ↗

Molecular analysis of the membrane insertion domain of proteinase 3, the Wegener's autoantigen, in RBL cells: implication for its pathogenic activity.Semantic proximity Read ↗

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Effects of carboxy-terminal modifications of proteinase 3 (PR3) on the recognition by PR3-ANCA.Semantic proximity Read ↗

[Pathophysiology of ANCA-associated vasculitides].Semantic proximity Read ↗

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