Article
A large subset of neutrophils expressing membrane proteinase 3 is a risk factor for vasculitis and rheumatoid arthritis.
Journal of the American Society of Nephrology : JASN - 1 Jun 1999
Witko-Sarsat V, Lesavre P, Lopez S, Bessou G, Hieblot C, Prum B, Noël L H, Guillevin L, Ravaud P, Sermet-Gaudelus I, Timsit J, Grünfeld J P, Halbwachs-Mecarelli L
Abstract excerpt
It has been shown previously that proteinase 3 (PR3), a neutrophil intracellular protease that is the main antigen of antineutrophil cytoplasm (ANCA) autoantibodies, is present on the plasma membrane of a subset of freshly isolated neutrophils. This study shows that the size of this subset of membrane PR3-positive (mPR3+) neutrophils is a stable feature of a given individual, most likely genetically controlled....
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