Article
Genetically distinct subsets within ANCA-associated vasculitis.
The New England journal of medicine - 19 Jul 2012
Lyons Paul A, Rayner Tim F, Trivedi Sapna, Holle Julia U, Watts Richard A, Jayne David R W, Baslund Bo, Brenchley Paul, Bruchfeld Annette, Chaudhry Afzal N, Cohen Tervaert Jan Willem, Deloukas Panos, Feighery Conleth, Gross Wolfgang L, Guillevin Loic, Gunnarsson Iva, Harper Lorraine, Hrušková Zdenka, Little Mark A, Martorana Davide, Neumann Thomas, Ohlsson Sophie, Padmanabhan Sandosh, Pusey Charles D, Salama Alan D, Sanders Jan-Stephan F, Savage Caroline O, Segelmark Mårten, Stegeman Coen A, Tesař Vladimir, Vaglio Augusto, Wieczorek Stefan, Wilde Benjamin, Zwerina Jochen, Rees Andrew J, Clayton David G, Smith Kenneth G C
Abstract excerpt
BACKGROUND: Antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis is a severe condition encompassing two major syndromes: granulomatosis with polyangiitis (formerly known as Wegener's granulomatosis) and microscopic polyangiitis. Its cause is unknown, and there is debate about whether it is a single disease entity and what role ANCA plays in its pathogenesis. We investigated its genetic basis. METHODS:...
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