Genetic impact of pathogenesis and prognosis of ANCA-associated vasculitides.

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Article

Genetic impact of pathogenesis and prognosis of ANCA-associated vasculitides.

Clinical and experimental rheumatology - 1 Jan 2004

Borgmann S, Haubitz M

Abstract excerpt

Wegener's granulomatosis (WG), microscopic polyangiitis (MPA) and the Churg-Strauss syndrome (CSS) are small vessel vasculitides associated with anti-neutrophil cytoplasmic antibodies (ANCA). Cytoplasmic (c)-ANCA mainly target proteinase 3 (PR3) and are often observed in WG patients, while perinuclear (p)-ANCA predominantly bind to myeloperoxidase (MPO) and are common in patients with MPA and CSS. It is suspected...

Topics

Antibodies, Antineutrophil Cytoplasmic
Genetic Predisposition to Disease
Humans
Myeloblastin
Peroxidase
Prognosis
Serine Endopeptidases
Vasculitis

Source

Open in PubMed

Identifiers

PMID: 15675141

Genes

MPO
CCR5

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

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