Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Genetic impact of pathogenesis and prognosis of ANCA-associated vasculitides.

Clinical and experimental rheumatology - 1 Jan 2004

Borgmann S, Haubitz M

Abstract excerpt

Wegener's granulomatosis (WG), microscopic polyangiitis (MPA) and the Churg-Strauss syndrome (CSS) are small vessel vasculitides associated with anti-neutrophil cytoplasmic antibodies (ANCA). Cytoplasmic (c)-ANCA mainly target proteinase 3 (PR3) and are often observed in WG patients, while perinuclear (p)-ANCA predominantly bind to myeloperoxidase (MPO) and are common in patients with MPA and CSS. It is suspected...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Antibodies, Antineutrophil Cytoplasmic
Share to CCR5 gene
Share to MPO gene

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Genetic Predisposition to Disease

Share to Peroxidase

Share to Prognosis

Share to Serine Endopeptidases

Share to Vasculitis

Source

Identifiers

PMID: 15675141

Genes

MPO
CCR5

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Genetic impact of pathogenesis and prognosis of ANCA-associated vasculitides.PMID 15675141Read ↗

Genetics and pathophysiology of granulomatosis with polyangiitis (GPA) and its main autoantigen proteinase 3.Semantic proximity Read ↗

Genetics of ANCA-associated vasculitides: HLA and beyond.Semantic proximity Read ↗

Complex genetics of Wegener granulomatosis.Semantic proximity Read ↗

Genetic aspects of anti-neutrophil cytoplasmic antibody-associated vasculitisSemantic proximity Read ↗

Proteinase 3 gene polymorphisms and Wegener's granulomatosis.Semantic proximity Read ↗

Genetically distinct subsets within ANCA-associated vasculitis.Semantic proximity Read ↗

Recent pathogenetic advances in ANCA-associated vasculitis.Semantic proximity Read ↗

Antineutrophil Cytoplasmic Antibody-Associated Vasculitis Update: Genetic Pathogenesis.Semantic proximity Read ↗

Republished: Antineutrophil cytoplasmic antibody-associated vasculitides: is it time to split up the group?Semantic proximity Read ↗

-463 G/A myeloperoxidase promoter polymorphism is associated with clinical manifestations and the course of disease in MPO-ANCA-associated vasculitis.Semantic proximity Read ↗

Major histocompatibility complex HLA region largely explains the genetic variance exercised on neutrophil membrane proteinase 3 expression.Semantic proximity Read ↗

Genetics of ANCA-associated Vasculitides.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.