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Article

Major histocompatibility complex HLA region largely explains the genetic variance exercised on neutrophil membrane proteinase 3 expression.

Journal of the American Society of Nephrology : JASN - 1 Nov 2006

von Vietinghoff Sibylle, Busjahn Andreas, Schönemann Constanze, Massenkeil Gero, Otto Björn, Luft Friedrich C, Kettritz Ralph

Abstract excerpt

ANCA-associated vasculitides, a common cause of rapidly progressive glomerulonephritis, are influenced by genetic variance. Neutrophil membrane expression of the ANCA antigen proteinase 3 (PR3) is pathogenically important. A subset of membrane PR3-positive neutrophils can be distinguished from a membrane-negative subset in any given subject. The percentage of membrane PR3-positive neutrophils is genetically...

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PMID: 17005932
DOI: 10.1681/ASN.2006050522

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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