Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Genetics and pathophysiology of granulomatosis with polyangiitis (GPA) and its main autoantigen proteinase 3.

Molecular and cellular probes - 1 Dec 2016

Relle Manfred, Föhr Bernd, Fasola Federica, Schwarting Andreas

Abstract excerpt

Granulomatosis with polyangiitis (GPA) is a severe autoimmune disease and one of the small vessel anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitides. Although its etiology and pathophysiology are still widely unknown, it is accepted that infections, environmental factors, epigenetic modifications, and a genetic predisposition provide the basis for this systemic disorder. GPA typically evolves...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis
Share to Antibodies, Antineutrophil Cytoplasmic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Autoantigens

Share to SERPINA1 gene

Share to Genetic Predisposition to Disease

Share to Genome-Wide Association Study

Share to Granulomatosis with Polyangiitis

Source

Identifiers

PMID: 27559009
DOI: 10.1016/j.mcp.2016.08.009

Genes

CTLA4
PTPN22
SERPINA1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Genetics and pathophysiology of granulomatosis with polyangiitis (GPA) and its main autoantigen proteinase 3.PMID 27559009Read ↗

Antineutrophil Cytoplasmic Antibody-Associated Vasculitis Update: Genetic Pathogenesis.Semantic proximity Read ↗

Type of ANCA may be Superior to Clinical Phenotype in Distinguishing Different Clinical Entities in ANCA-associated VasculitisSemantic proximity Read ↗

Republished: Antineutrophil cytoplasmic antibody-associated vasculitides: is it time to split up the group?Semantic proximity Read ↗

Genetics of ANCA-associated vasculitides: HLA and beyond.Semantic proximity Read ↗

Pathogenesis of ANCA-associated vasculitis: new possibilities for intervention.Semantic proximity Read ↗

Genetic aspects of anti-neutrophil cytoplasmic antibody-associated vasculitisSemantic proximity Read ↗

Epidemiology and clinical features of systemic vasculitis.Semantic proximity Read ↗

[Pathophysiology of ANCA-associated vasculitides].Semantic proximity Read ↗

Genetically distinct subsets within ANCA-associated vasculitis.Semantic proximity Read ↗

Genetic impact of pathogenesis and prognosis of ANCA-associated vasculitides.Semantic proximity Read ↗

Granulomatosis with polyangiitis (Wegener): clinical aspects and treatment.Semantic proximity Read ↗

Genetically distinct clinical subsets, and associations with asthma and eosinophil abundance, within Eosinophilic Granulomatosis with PolyangiitisSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.