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Article

Molecular analysis of the membrane insertion domain of proteinase 3, the Wegener's autoantigen, in RBL cells: implication for its pathogenic activity.

Journal of leukocyte biology - 1 Nov 2011

Kantari Chahrazade, Millet Arnaud, Gabillet Julie, Hajjar Eric, Broemstrup Torben, Pluta Paula, Reuter Nathalie, Witko-Sarsat Véronique

Abstract excerpt

PR3, also called myeloblastin, is a neutrophil serine protease that promotes myeloid cell proliferation by cleaving the cyclin-dependent kinase inhibitor p21(cip1/waf1). In addition, it is the target of ANCA in GPA, a necrotizing vasculitis. Anti-PR3 ANCA binding to membrane-expressed PR3 trigger...

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Source

Identifiers

PMID: 21821719
DOI: 10.1189/jlb.1210695

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-21821719-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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Molecular analysis of the membrane insertion domain of proteinase 3, the Wegener's autoantigen, in RBL cells: implication for its pathogenic activity.PMID 21821719Read ↗

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