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Article

Constitutive membrane expression of proteinase 3 (PR3) and neutrophil activation by anti-PR3 antibodies.

Journal of leukocyte biology - 1 Dec 2004

van Rossum André P, Rarok Agnieszka A, Huitema Minke G, Fassina Giorgio, Limburg Pieter C, Kallenberg Cees G M

Abstract excerpt

Antineutrophil cytoplasm autoantibodies with specificity for proteinase 3 (PR3) are thought to play a major role in the pathogenesis of Wegener's granulomatosis (WG), presumably by their potential to activate neutrophils. In patients with WG, high expression of PR3 on the surface of nonprimed neutrophils is associated with an increased incidence and rate of relapse. In this study, we analyzed the functional...

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Identifiers

PMID: 15331626
DOI: 10.1189/jlb.0604319

Genes

TNF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Constitutive membrane expression of proteinase 3 (PR3) and neutrophil activation by anti-PR3 antibodies.PMID 15331626Read ↗

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