Bimodal distribution of proteinase 3 (PR3) surface expression reflects a constitutive heterogeneity in the polymorphonuclear neutrophil pool.

doi:10.1016/0014-5793(95)01073-n

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Article

Bimodal distribution of proteinase 3 (PR3) surface expression reflects a constitutive heterogeneity in the polymorphonuclear neutrophil pool.

FEBS letters - 23 Oct 1995

Halbwachs-Mecarelli L, Bessou G, Lesavre P, Lopez S, Witko-Sarsat V

Abstract excerpt

Proteinase 3, which is known as an intracellular serine protease of neutrophils, was detected at the surface of a subpopulation of freshly isolated PMN. The proportion of PR3-positive and -negative PMN, observed by flow cytometry with anti-PR3 mAbs or ANCA autoantibodies, varies among individuals...

Topics

Animals
Arthritis, Rheumatoid
Autoantibodies
Blood Donors
Cell Membrane
Granulomatosis with Polyangiitis
Humans
Mice
Myeloblastin
N-Formylmethionine Leucyl-Phenylalanine
Neutrophils
Phenotype
Serine Endopeptidases

Source

Open in PubMed

Identifiers

PMID: 7589506
DOI: 10.1016/0014-5793(95)01073-n

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-7589506-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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