Article
The PML gene is not involved in the regulation of MHC class I expression in human cell lines.
Blood - 1 May 2003
Bruno Silvia, Ghiotto Fabio, Fais Franco, Fagioli Marta, Luzi Lucilla, Pelicci Pier Giuseppe, Grossi Carlo Enrico, Ciccone Ermanno
Abstract excerpt
The promyelocytic leukemia gene, PML, is a growth and transformation suppressor. An additional role for PML as a regulator of major histocompatibility complex (MHC) class I antigen presentation has been proposed in a murine model, which would account for evasion from host immunity of tumors bearing malfunctioning PML, such as acute promyelocytic leukemia. Here we investigated a possible role of PML for the...
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