Article
Suppression of basal, PMA- and IFN-alpha-, but not IFN-gamma-induced expression of HLA class I in v-myc-transformed U-937 monoblasts.
International journal of cancer - 11 Nov 1992
Larsson L G, Oberg F, Stöckbauer P, Masucci M G, Nilsson K
Abstract excerpt
Recent studies have suggested that certain oncogenes, in particular members of the myc family, may be involved in the down-regulation of HLA class-I antigen expression observed in many types of tumor. We report that constitutive expression of an OK10 v-myc gene in human monoblastic U-937 cells re...
Topics
- Alleles
- Antigens, CD
- CD11 Antigens
- Cell Division
- Cell Transformation, Viral
- Gene Expression Regulation
- Genes, myc
- Histocompatibility Antigens Class I
- Humans
- Interferon-alpha
- Interferon-gamma
- Monocytes
- RNA, Messenger
- Tetradecanoylphorbol Acetate
- Tumor Cells, Cultured