Article

Gene knockout shows that PML (TRIM19) does not restrict the early stages of HIV-1 infection in human cell lines

2017-02-19

Abstract excerpt

The PML (promyelocytic leukemia) protein is a member of the TRIM family, a large group of proteins that show high diversity in functions but possess a common tripartite motif giving the family its name. We and others recently reported that both murine PML (mPML) and human PML (hPML) strongly restrict the early stages of infection by HIV-1 and other lentiviruses when expressed in mouse embryonic fibroblasts (MEFs)....

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Literature Corpus work: 99ab28b5-38e1-5938-8028-f160d16a569d
DOI: 10.1101/109769

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