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Article

Disruption of PML-associated nuclear bodies during human cytomegalovirus infection

1 Nov 1995

Abstract excerpt

PML is a protein associated with discrete spherical structures within the nucleus of normal cells. A defect in PML expression is observed in acute promyelocytic leukaemia as a consequence of a chromosomal translocation involving the genes encoding PML and the alpha retinoic acid receptor (RAR alpha). Disruption of PML bodies also occurs during herpes simplex virus infection after the immediate early protein...

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PMID: 7595400
DOI: 10.1099/0022-1317-76-11-2887

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