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Article

Structure-function analysis of the streptokinase amino terminus (residues 1-59).

The Journal of biological chemistry - 4 Jul 2003

Mundada Lakshmi V, Prorok Mary, DeFord Melanie E, Figuera Mariana, Castellino Francis J, Fay William P

Abstract excerpt

Streptokinase (SK) binds to plasminogen (Pg) to form a complex that converts substrate Pg to plasmin. Residues 1-59 of SK regulate its capacity to induce an active site in bound Pg by a nonproteolytic mechanism and to activate substrate Pg in a fibrin-independent manner. We analyzed 24 SK mutants to better define the functional properties of SK-(1-59). Mutations within the alphabeta1 strand (residues 17-26) of SK...

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Identifiers

PMID: 12704199
DOI: 10.1074/jbc.M301825200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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