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Article

Mutation of lysines in a plasminogen binding region of streptokinase identifies residues important for generating a functional activator complex.

Biochemistry - 24 Dec 1996

Lin L F, Oeun S, Houng A, Reed G L

Abstract excerpt

Through a unique but poorly understood mechanism, streptokinase (SK) interacts with human plasminogen to generate an "activator complex" that efficiently cleaves substrate plasminogen molecules. Previous studies have suggested that lysine residues in SK may play a role in the binding and function of the activator complex. To investigate this hypothesis, 10 different lysine residues in the plasminogen binding...

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Identifiers

PMID: 8988027
DOI: 10.1021/bi961531w

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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