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Article

Human IL-21 and IL-4 bind to partially overlapping epitopes of common gamma-chain.

Biochemical and biophysical research communications - 10 Jan 2003

Zhang Jin-Li, Foster Don, Sebald Walter

Abstract excerpt

Interleukin 21 (IL-21) is a recently identified novel cytokine that plays an important role in the regulation of B, T, and NK cell functions. Its effects depend on binding to and signaling through an IL-21 receptor complex consisting of the IL-21 receptor (IL-21R) and the common gamma-chain (gamma(c)). In this study using biosensor technique, the ligand-binding properties of IL-21R and gamma(c), which are...

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PMID: 12504082
DOI: 10.1016/s0006-291x(02)02836-x

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