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Article

IFN-α regulates IL-21 and IL-21R expression in human NK and T cells

3 Jun 2004

Abstract excerpt

Interleukin (IL)-21 is a T cell-derived cytokine that regulates innate and adaptive immune responses. IL-21 receptor (IL-21R), which is expressed in natural killer (NK) and T cells, is structurally homologous to IL-2Rbeta and IL-15Ralpha. These receptors also share a common cytokine receptor gamma-chain with IL-4, IL-7, and IL-9. Macrophage- or dendritic cell-derived interferon (IFN)-alpha/beta is a key cytokine...

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Identifiers

PMID: 15178704
DOI: 10.1189/jlb.1003488

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