Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

[Analysis of gammac-dependent cytokines-mediated immunoregulation].

Rinsho byori. The Japanese journal of clinical pathology - 1 Jan 2007

Asao Hironobu

Abstract excerpt

In the study of interleukin-2 (IL-2) -induced signal transduction system, we identified and cloned the third component of IL-2 receptor, IL-2Rgamma chain. Functional high affinity IL-2 receptor consists of three subunits, alpha, beta and gamma chains. Interestingly not only IL-2 but also IL-4, IL-7, IL-9, IL-15 and IL-21 utilize the gamma chain as an essential component of each receptors. Therefore the gamma...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Genetic Therapy
Share to Interleukin-21
Share to Interleukin Receptor Common gamma Subunit

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Interleukins

Share to Lymphocytes

Share to Mutation

Share to Receptors, Interleukin-2

Source

Identifiers

PMID: 17319491

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

[Analysis of gammac-dependent cytokines-mediated immunoregulation].PMID 17319491Read ↗

The γc family of cytokines: fine-tuning signals from IL-2 and IL-21 in the regulation of the immune responseSemantic proximity Read ↗

Function of the interleukin-2 (IL-2) receptor gamma-chain in biologic responses of X-linked severe combined immunodeficient B cells to IL-2, IL-4, IL-13, and IL-15.Semantic proximity Read ↗

Functional role of interleukin-4 (IL-4) and IL-7 in the development of X-linked severe combined immunodeficiency.Semantic proximity Read ↗

Characterization of the gammac chain among 27 unrelated Japanese patients with X-linked severe combined immunodeficiency (X-SCID).Semantic proximity Read ↗

Human IL-21 and IL-4 bind to partially overlapping epitopes of common gamma-chain.Semantic proximity Read ↗

Patients with T⁺/low NK⁺ IL-2 receptor γ chain deficiency have differentially-impaired cytokine signaling resulting in severe combined immunodeficiency.Semantic proximity Read ↗

A novel mutant gammac chain from a patient with typical phenotype of X-linked severe combined immunodeficiency (SCID) has partial signalling function for mediating IL-2 and IL-4 receptor action.Semantic proximity Read ↗

Both integrated and differential regulation of components of the IL-2/IL-2 receptor system.Semantic proximity Read ↗

[Gene therapy of X-linked severe combined immunologic deficiency (SCID-X1)].Semantic proximity Read ↗

Preclinical ex vivo IL2RG gene therapy using autologous hematopoietic stem cells as an effective and safe treatment for X-linked severe combined immunodeficiency diseaseSemantic proximity Read ↗

A novel common gamma chain mutation in a Chinese family with X-linked severe combined immunodeficiency (X-SCID; T(-)NK(-)B(+)).Semantic proximity Read ↗

X-linked severe combined immunodeficiency: from molecular cause to gene therapy within seven years.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.