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Article

Three loops of the common gamma chain ectodomain required for the binding of interleukin-2 and interleukin-7.

The Journal of biological chemistry - 29 Sept 2000

Olosz F, Malek T R

Abstract excerpt

The common gamma chain (gammac), a subunit of the interleukin (IL)-2, IL-4, IL-7, IL-9, and IL-15 receptors, contributes to both cytokine binding and subsequent signal transduction. Using a model-based site-directed mutagenesis strategy, we have identified residues of the mouse gammac extracellular domain that are required for normal gammac-dependent enhancement of IL-2 and IL-7 binding. One of these sites,...

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Source

Identifiers

PMID: 10887198
DOI: 10.1074/jbc.M004976200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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