Article
Dissociation of its opposing immunologic effects is critical for the optimization of antitumor CD8+ T-cell responses induced by interleukin 21.
Clinical cancer research : an official journal of the American Association for Cancer Research - 1 Oct 2008
Ansén Sascha, Butler Marcus O, Berezovskaya Alla, Murray Andrew P, Stevenson Kristen, Nadler Lee M, Hirano Naoto
Abstract excerpt
PURPOSE: Interleukin 21 (IL-21) is a promising new cytokine, which is undergoing clinical testing as an anticancer agent. Although IL-21 provides potent stimulation of CD8(+) T cells, it has also been suggested that IL-21 is immunosuppressive by counteracting the maturation of dendritic cells. The dissociation of these two opposing effects may enhance the utility of IL-21 as an immunotherapeutic. In this study,...
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