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Article

An engineered IL-21 variant is a potent antitumor candidate for antitumor immunotherapy.

Acta pharmacologica Sinica - 1 Mar 2026

Wu Hui, Cheng Ya-Ping, Liu Yu-Long, Zhu Ruo-Han, Ji Li-Wen, Wang Ming-Kai, Li Quan-Xiao, Shen Zhao-Ling, Ying Tian-Lei, Wu Yan-Ling

Abstract excerpt

IL-21, as an immune agonist, has demonstrated limited therapeutic efficacy in cancer immunotherapy. To overcome this inherent limitation, we constructed a yeast surface-displayed IL-21 mutant library guided by the structure of the IL-21/IL-21 receptor (IL-21R). Following one round of magnetic bead sorting and three rounds of fluorescence-activated cell sorting, several variants were isolated and evaluated for...

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Identifiers

PMID: 41107402
DOI: 10.1038/s41401-025-01652-1
PMCID: PMC12932829

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STAT3

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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