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Article

Structural basis for binding multiple ligands by the common cytokine receptor gamma-chain.

The Journal of biological chemistry - 5 Apr 2002

Olosz Ferenc, Malek Thomas R

Abstract excerpt

The common gamma-chain (gamma(c)) that functions both in ligand binding and signal transduction is a shared subunit of the multichain receptors for interleukin (IL)-2, IL-4, IL-7, IL-9, IL-15, and IL-21. The structural basis by which the ectodomain of gamma(c) contributes to binding six distinct cytokines is only partially defined. In the present study, epitope mapping of antagonistic anti-gamma(c) monoclonal...

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Identifiers

PMID: 11815609
DOI: 10.1074/jbc.M110520200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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