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Article

IL-21 promotes differentiation of naive CD8 T cells to a unique effector phenotype.

Journal of immunology (Baltimore, Md. : 1950) - 15 Jun 2007

Casey Kerry A, Mescher Matthew F

Abstract excerpt

IL-21, the most recently described member of the common gamma-chain cytokine family, is produced by activated CD4 T cells, whereas CD8 T cells express the IL-21 receptor. To investigate a possible role for IL-21 in the priming of naive CD8 T cells, we examined responses of highly purified naive OT-I CD8 T cells to artificial APCs displaying Ag and B7-1 on their surface. We found that IL-21 enhanced OT-I clonal...

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Identifiers

PMID: 17548600
DOI: 10.4049/jimmunol.178.12.7640

Genes

STAT4

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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