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Article

IL-21 promotes differentiation of naive CD8 T cells to a unique effector phenotype.

Journal of immunology (Baltimore, Md. : 1950) - 15 Jun 2007

Casey Kerry A, Mescher Matthew F

Abstract excerpt

IL-21, the most recently described member of the common gamma-chain cytokine family, is produced by activated CD4 T cells, whereas CD8 T cells express the IL-21 receptor. To investigate a possible role for IL-21 in the priming of naive CD8 T cells, we examined responses of highly purified naive O...

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Identifiers

PMID: 17548600
DOI: 10.4049/jimmunol.178.12.7640

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STAT4

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-17548600-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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