Advances of the interleukin-21 signaling pathway in immunity and angiogenesis

Abstract excerpt

Interleukin‑21 (IL‑21) and its receptor (IL‑21R) are broadly expressed on human B cells, activated T cells and other myeloid cells. IL‑21 cooperates with IL‑6 and transforming growth factor‑β to regulate T‑cell differentiation. IL‑21‑mediated human B cell and dendritic cells differentiation requires signal transducer and activator of transcription 3 (STAT3), and also induces B‑cell apoptosis dependents on the...

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